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KMID : 0363320070280020209
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 2 p.209 ~ p.216
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Effect of Jungjungamiyjintang(JGT) on Gastric Emptying of Spregue-Dawley rat
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Nam Hyo-Ik
Kim Hoi-Young
Son Hyun-Soo
Lim Sung-Woo
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Abstract
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Background & Objective : The herbal medicine JGT has been used for the treatment of functional dyspepsia, generally categorized as a gastric disease. However, its effect and mechanism are not yet well known. Therefore, the effects of JGT on gastric emptying in rats was investigated to know its effectiveness and mechanism.
Methods : Gastric emptying effect was measured by the number of glass beads expelled from the stomach within an hour after glass beads and test drugs were administered. In another series of experiments to evaluate the mechanisms of JGT under delayed conditions, the rats were treated with atropine sulfate
Results : Intragastric administration of JGT significantly increased gastric emptying of glass beads Under the gastric emptying delayed with atropine sulfate, JGT insignificantly increased gastric emptying of glass beads.
Conclusions : These suggest that JGT has a significant effect to stimulate gastric emptying. Results are indicative of JGT as an especially effective remedy for dysmotility-like functional dyspepsia with impaired reservoir function such as gastric adaptive relaxation.
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KEYWORD
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JGT, Gastric emptying, Atropine sulfate
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